Smoking Brisket at 250 vs 225 Degrees: Which is the Best? All cuts of meat benefit from good preparation and cooking but none more so than a brisket. Cooked too quickly, this reasonably priced piece of beef might still retain flavor but your jaw muscles are sure to get a workout – the word tough doesn’t begin to describe it! However, when cooked long and slow, brisket can be a culinary masterpiece. Here we will discuss smoking brisket at 250 vs 225 °F.
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